Borstelmann broke away at kilometer 35 of the section, which he traveled in 04:04:58 hours, surpassing Alfredo Rodríguez (Best Buddies Racing) and his teammate Coles Davis (VFT), who arrived in the pack one minute and 23 seconds behind the new leader.
Dominican Alberto Ramos (Team EDA) and Camilo Torres (Team Gespron Evolution) placed fourth and fifth, respectively.
With this victory, Borstelmann took the overall leader and regularity jerseys with a difference of one minute and 31 seconds from the rest of the peloton.
Colombian Fredd Matute (Herrera Sport-Sportswear), who was accompanying Borstelmann in the breakaway but faced mechanical problems with 10 kilometers to go, is the mountain leader with 10 points, followed by the American (8) and Rubén Acosta (Herrera Sport) with three points.
Matute also leads the intermediate sprints classification with six points; Borstelmann has 8, and Venezuelan Luis Gómez (Arroz Fina) three points.
Colombian Javier Moreno (Herrera Sport) is the leader of the Under-23 category with 04:06:21 hours, followed at the same time by Venezuelan Johnny Araujo (Arroz Fina-Banesco) and Anuar David Castillo (Gespron Evolution), second and third, respectively.
The Herrera Sport-Clothing Sports team leads the team classification with 12 hours, 19 minutes and three seconds.
Best Buddies Racing and EDA-Good Bike-AC Training are second and third with the same time as the Colombian squad.