Home Science The first five cases of accidental transmission of Alzheimer’s disease are discovered

The first five cases of accidental transmission of Alzheimer’s disease are discovered

The first five cases of accidental transmission of Alzheimer's disease are discovered

A Investigation The study conducted in the United Kingdom confirmed for the first time that accidental transmissionthrough medical treatment, Alzheimer’s-causing protein. Until now, this has been a disease linked only to age or, to a lesser extent, genetic inheritance.

For the authors of this study, published in the journal “Natural medicinethe discovery of this spread, no matter how extraordinary the circumstances in which it occurred, highlights the need to do so Take extreme precautions.

The study confirmed that there were five patients treated with a growth hormone contaminated – coming from Brain tissue from corpses and had not been used since 1985, eventually developed the disease without age or genetics being related. That was contaminated with amyloid beta proteinthe accumulation of which is responsible for Alzheimer’s disease.

A contaminated treatment

The growth hormone c-hGH, extracted from the pituitary glands of deceased people to treat altitude problems, was given to 1,848 girls and boys in the UK between 1959 and 1985. This method was discontinued in 1985 and replaced with a synthetic hormone – after it was discovered that some batches contained infectious proteins that cause Creutzfeldt-Jakob disease, a brain disorder that often leads to dementia.

In 2017–2018, more than 30 years after this treatment stopped being used, the authors of the present study analyzed stored samples of the growth hormone c-hGH and found that, despite its use, it was associated with amyloid beta protein pathology contaminated were stored for decades.

When they were given to mice, they found that they developed Alzheimer’s disease, which led them to wonder what might have been the cause. Development of the girls and boys who received this treatment possibly contaminated with amyloid beta protein.

“Our suspicion was that people who were exposed to this growth hormone did not succumb to Creutzfeldt-Jakob disease and lived longer, perhaps suffering from Alzheimer’s disease,” explained one of the authors, neurosurgeon John Collinge of University College London.

To this end, they examined eight cases, five of which had already begun to appearr symptoms of dementia between the ages of 38 and 55, and currently they have either been diagnosed with Alzheimer’s disease or meet all diagnostic criteria for the disease. Another of the people examined met the criteria for mild cognitive impairment.

The unusually early age at which these patients developed symptoms suggests that they did not suffer from the usual age-related Alzheimer’s disease, and in all five cases the existence of the gene that makes this disease hereditary in some cases has been ruled out.

“It’s nothing that should worry people.”

In light of this discovery, scientists emphasize that “there is no evidence that Alzheimer’s disease is present.” can be transmitted between people during activities of daily living or routine medical care.” There is also no evidence to “raise concerns that current surgical procedures pose a risk of transmission of the disease,” so “it is not something people should be concerned about. “

However, they agree that they should, now that they know that Alzheimer’s could be transmitted, no matter how extraordinary the circumstances Review of measures to prevent accidental transmission through medical or surgical interventions to prevent these cases from occurring in the future.

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