Ibuprofen in combination with most prescribed high blood pressure medications can cause irreparable damage to the kidneys
Scientists at the University of Waterloo have found that anyone taking a diuretic and a renin-angiotensin system (RSA) inhibitor for hypertension should exercise caution when taking ibuprofen, as there is a high risk of permanent kidney damage. The study was published in Mathematical Biosciences and directed by Anita Layton.
Diuretics and inhibitors of the renin-angiotensin system are often prescribed together for people with hypertension and are available under various pharmaceutical brand names. The most prescribed in Spain are Enalapril, Ramipril and Lisinopril.
While blood pressure medications require a prescription, pain relievers such as ibuprofen are available over-the-counter and many people take them daily. Ibuprofen is one of the so-called non-steroidal anti-inflammatory drugs, and there is increasing evidence of its different side effects, including stomach damage, risks during pregnancy, erectile dysfunction, increased cardiovascular risk and, in addition, kidney damage.
The combination can cause acute kidney injury, which in some cases can be permanent.
In the study, the team used computer-simulated drug tests to model the interactions of the three drugs and the impact on the kidney. They found that in people with certain medical profiles, the combination can cause acute kidney injury, which in some cases can be permanent.
The team says that not everyone who takes this drug combination will have problems, but the study shows that it can be a problem that people should be very careful about.
The research can also speak directly to many people on high blood pressure medication who might turn to an ibuprofen pain reliever without much thought.
Diuretics are a family of drugs that cause the body to retain less water. Being dehydrated is a major factor in acute kidney injury, so the combination of diuretics with the RAS inhibitor and ibuprofen attacks the kidney from three directions at once.
According to the researchers, people who are taking these high blood pressure medications and need a pain reliever should consider acetaminophen.