An FMD diet that mimics fasting reduces the risk of aging and disease

A diet similar in effect to fasting reduces disease risk factors and reduces a person’s biological age

A study from the University of South Carolina shows how cycles of a fasting-like diet reduce insulin resistance, liver fat, immune system aging and biological age in patients in clinical trials.

Cycles of a fasting-like diet reduce signs of immune system aging as well as insulin resistance and liver fat in humans, leading to a lower biological age, according to a new study from the USC Leonard Davis School of Gerontology.

The study, which appears in Nature Communications, adds to the evidence for the positive effects of the fasting-like diet (FMD). The FMD is a 5-day diet that is high in unsaturated fats and low in calories, proteins and carbohydrates. It is intended to mimic the effects of a water-only fast while providing the necessary nutrients and making it easier for people to end the fast. The diet was developed by the laboratory of Valter Longo, a professor at the USC Leonard Davis School, the lead author of the new study.

“This study shows for the first time evidence of a reduction in biological age from two different clinical trials, accompanied by evidence of rejuvenation in metabolic and immune function,” Longo said.

Previous research led by Longo has suggested that short, periodic courses of FMD are associated with a number of positive effects, including promoting stem cell regeneration, reducing chemotherapy side effects and reducing signs of dementia in mice, as well as reducing risk factors in cancer, diabetes, heart disease and other age-related human diseases. The Longo lab had also previously shown that one or two cycles of FMD for five days per month extended the healthspan and lifespan of mice on a normal or Western diet, but until now the effects of FMD were unknown. on aging and biological age, liver fat and immune system aging in humans.

Lower risk of disease and younger cells

The study examined the effects of the diet in two clinical study populations, each consisting of men and women between the ages of 18 and 70. Patients randomly assigned to the fasting-like diet underwent 3-4 monthly cycles, followed FMD for 5 days, and then followed a normal diet for 25 days. FMD consists of vegetable soups, energy bars, energy drinks, potato chip snacks and tea in 5-day portions, as well as a dietary supplement that provides high levels of minerals, vitamins and essential fatty acids. Patients in the control groups were instructed to eat a normal or Mediterranean diet.

An analysis of blood samples from study participants showed that patients in the FMD group had lower diabetes risk factors, including lower insulin resistance and lower HbA1c levels. MRI scans also showed a decrease in abdominal fat and fat in the liver, improvements that are associated with a lower risk of metabolic syndrome. Additionally, FMD cycles appeared to increase the lymphoid to myeloid ratio, an indicator of a younger immune system.

FMD participants had their biological age reduced by an average of 2.5 years

Further statistical analysis of the results of both clinical trials found that FMD participants had reduced their biological age – a measure of how a person’s cells and tissues function, as opposed to chronological age – by an average of 2.5 years.

“This is the first study to show that a nutrition-based intervention that does not require chronic diet or lifestyle changes can biologically rejuvenate people, both based on changes in risk factors for aging and disease and in a validated way Method developed by Levine’s group.” “Assess biological age,” Longo said.

The study by lead authors Sebastian Brandhorst, associate research professor at USC Leonard Davis, and Morgan E. Levine, founding director of Altos Labs and former graduate student at USC Leonard Davis, further supports the near-term potential of MKS. Regular nutritional interventions that can help people reduce their risk of disease and improve their health without having to make major lifestyle changes, Longo said.

“Although many physicians in the US and Europe already recommend FMD, these results should encourage many more healthcare professionals to recommend FMD cycles to patients with higher disease risk factors than desired, as well as to the general population who may be interested in increasing their FMD cycles “I’m interested in function and aging younger,” Longo said.


A fasting-mimicking diet results in changes in liver and blood markers, indicating reduced biological age and disease risk

Source: USC

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